Cutaneous lymphoma in a cow – a case report
Article Sidebar
Main Article Content
Abstract
In this paper a case of two years and six months old Simmental cow, in which there was a suspicion of lumpy skin disease in mid-2017 in Serbia is present. According to the results of the laboratory analysis, the cow was negative for the presence of antibodies against the bovine leukemia virus, showed a negative reaction in tuberculinization and was vaccinated against lumpy skin disease virus. A clinical examination revealed numerous nodules of varied size from a few millimeters to approximately 10 centimeters disseminated dominantly on the skin of the udder and the perineum, some of which were connected and exulcerated. The general condition of the cow was unchanged. After the surgical excision of the skin node, the sample was tested negative for the genome of lumpy skin disease virus. In order to establish the morphology of the skin lesion, a histopathological analysis was performed. Histopathological analysis showed the infiltration of the lamina propria and subcutaneous tissue by numerous mononuclear cells showing cellular atypia. Suspicion on the cutaneous lymphoma was established. Furthermore, the immunohistochemical examination confirmed that the infiltrate contains exclusively CD3 immunopositive cells suggesting T-cell origin nonepitheliotropic lymphoma.
Downloads
Article Details
Authors retain copyright of the published papers and grant to the publisher the right to publish the article, to be cited as its original publisher in case of reuse, and to distribute it in all forms and media. Articles will be distributed under the Creative Commons Attribution International License (CC BY 4.0).
References
Burg G., Kempf W., Cozzio A., Dobbeling U., Freit J., Golling P., Michaelis S., Scharer L., Nestle F., Dummer R. 2006. Cutaneous malignant lymphomas: Update 2006. Journal der Deutschen Dermatologischen Gesellschaft, 4:914-933. https://doi.org/10.1111/j.1610-0387.2006.06069.x.
Harbo S.J., Barrington G.M., Allen A.J., Sample G.L., Parish S.M., Hamilton M.J., Davis W.C. 2004. Characterization of lymphocyte populations by flow cytometry in a calf with sporadic juvenile lymphoma. Veterinary Clinical Pathology, 33:163-167.
Klinkon M., Cerne M. 2006. Cutaneous T-cell lymphoma in heifer with increased serum lactate dehydrogenase activity. Veterinary Clinical Pathology, 35:231-234. https://doi.org/10.1111/j.1939-165X.2006.tb00120.x.
Loh C.C. 2007. Atypical presentation of cutaneous T-cell lymphosarcoma in a 19-month-old Holstein heifer. Canadian Veterinary Journal, 48:309-311.
Lucas M.H. 1992. Enzootic bovine leukosis. In Bovine Medicine, eds. Andrews, A. H. et al., Blackwell Science, Oxford, 530-537.
Murayama S., Sato K., Ikehata T., Wada Y., Ishikawa Y., Kadota K. 2011. Cytologic and immunophenotypic investigation of lymphohematopoietic neoplasms in cattle. Japan Agricultural Research Quarterly, 45: 225-231. https://doi.org/10.6090/jarq.45.225.
OIE, 2017. Lumpy Skin Disease. Etiology, Epidemiology, Diagnosis, Prevention and Control References. Terrestrial Animal Health Code. OIE, Paris.
Oliver-Espinosa O., Physick-Sheard P.W., Wollenberg G.K., Taylor J. 1994. Sporadic bovine leukosis with ataxia and tibiotarsal joint swelling: A case report. The Canadian Veterinary Journal, 35:777-779.
Otrocka-Domagala I., Procajlo Z., Pazdzior K., Gesek M., Rotkiewicz T., Szweda W. 2012. Immunohistochemical profile of multicentric cutaneous epitheliotropic T-cell lymphoma with generalized lymphadenopathy in a Holstein-Friesian cow: a case report. Veterinarni Medicina, 57 (5):251-257.
Radostits O.M., Gay C.C., Hinchcliff K.W., Constable P.D. 2007. Veterinary Medicine, A textbook of the diseases of cattle, horses, sheep, pigs and goats. Saunders, 10th Edition.
Schweizer G., Hilbe M., Braun U. 2003. Clinical, haematological, immunohistochemical and pathological findings in 10 cattle with cutaneous lymphoma. Veterinary Record, 153:525-528. http://dx.doi.org/10.1136/vr.153.17.525.
Stober M. 1981. The clinical picture of the enzootic and sporadic forms of bovine leukosis. Bovine Practitioner, 16:119-129.
Theilen G. H., Madewell B. R. 1987. Bovine. In Veterinary Cancer Medicine, 2nd ed., eds., Lea & Febiger, Philadelphia, 408-430.
Vidanović D., Šekler M., Petrović T., Debeljak Z., Vasković N., Matović K., Hoffmann B. 2016. Real-time PCR assays for the specific detection of field Balkan strains of lumpy skin disease virus. Acta Veterinaria-Beograd, 66(4):444-454. DOI: 10.1515/acve-2016-0038.
Yamamoto S., Wada Y., Ishikawa Y., Kadota K. 2007. Precursor B-1 B cell lymphoma in a newborn calf. Journal of Veterinary Diagnostic Investigation, 19: 447-450. https://doi.org/10.1177%2F104063870701900422.