Autogenous vaccines in aquaculture: tool to combat resistance of bacteria to antibiotics?

Main Article Content

Dušan Palić
https://orcid.org/0000-0002-2980-821X
Ksenija Aksentijevic
https://orcid.org/0000-0003-2546-8366

Abstract

New technological progress and increased demands for fish as a source of animal protein are driving significant growth of aquaculture production. Intensification of production increases the severity and frequency of infectious disease outbreaks, and so requires significant effort to prevent and control disease. Because of the global crisis of bacterial resistance to antibiotics, the use of antibiotics in aquaculture is increasingly subjected to strict control and regulatory measures, leading to potential misuse. The lack of availability of approved veterinary medical products for use in aquaculture, combined with the risk of drug resistance development and antibiotic residues in fish flesh or water, support the development of preventive actions, including vaccines. However, the diversity of species and aquaculture production methods, including epidemiological units and their links, results in economic challenges for commercial vaccine development and authorization. As a possible response to the increasing demand for less antibiotic use in fish farms, and to the expenses associated with novel veterinary product development, there is a need for increased use of safe and effective autogenous vaccines in aquaculture. Regulatory processes for autogenous vaccine production, approval and application should recognize the specificities of epidemiological units and their links in aquatic animal production facilities. The joint efforts of regulatory authorities, producers, and veterinary services to follow veterinary biosecurity principles, including risk analysis, surveillance, and selection/prioritization of pathogens, are essential to provide maximum safety and efficacy of autogenous vaccines as disease prevention and control tools within larger areas, such as compartments and zones, and allow for reductions in antibiotic use.

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How to Cite
Palić, D., & Aksentijevic, K. (2022). Autogenous vaccines in aquaculture: tool to combat resistance of bacteria to antibiotics?. Veterinarski Glasnik, 76(2), 91-102. https://doi.org/10.2298/VETGL220926016P
Section
Review

References

Adams A. 2019. Progress, challenges and opportunities in fish vaccine development. Fish and Shellfish Immunology, 90:210-214. doi: 10.1016/j.fsi.2019.04.066. Epub 2019 Apr 27. PMID: 31039441.

Algammal AM., Mabrok M., Sivaramasamy E., Youssef FM., Atwa MH., El-kholy AW, Hetta HF., Hozzein WN. 2020. Emerging MDR-Pseudomonas aeruginosa in fish commonly harbor oprL and toxA virulence genes and blaTEM, blaCTX-M, and tetA antibiotic-resistance genes. Scientific Reports, 10: 15961. https://doi.org/10.1038/s41598-020-72264-4

Barnes, AC, Silayeva, O, Landos, M, Dong H., Lusiastuti A., Pkuoc L., Delamare-Deboutteville J. 2021. Autogenous vaccination in aquaculture: A locally enabled solution towards reduction of the global antimicrobial resistance problem. Review in Aquaculture; 14: 907- 918. https://doi.org/10.1111/raq.12633

Bondad-Reantaso, M.G., Arthur, J.R., Subasinghe, R.P. (eds). Understanding and applying risk analysis in aquaculture. FAO Fisheries and Aquaculture Technical Paper. No. 519. Rome, FAO. 2008. 304p.

Cabello FC., Godfrey HP., Tomova A., Ivanova L., Dölz H., Millanao A., Buschmann AH. 2013. Antimicrobial use in aquaculture re-examined: its relevance to antimicrobial resistance and to animal and human health. Environmental Microbiology, 15(7): 1917-1942. https://doi. org/10.1111/1462-2920.12134

Doherty, S., De Briyne, N., Palić, D., Toon, L., Fabris, A., Høy, T., Lopez, J., Nepejchalová, L., Norheim, K., Christophersen, H., Stapleton, K., Weeks, J. and Clayton, R. (2019). Barriers and solutions to get more authorised medicines for fish on the European market. FishMedPlus Coalition, Second Report. Federation of Veterinarians of Europe. 10.13140/RG.2.2.11050.06085.

EMAV (European Manufacturers of Autogenous Vaccines) 2021. Proposal: EU-GMP-Annex for Autogenous Vaccines_rev 01 – March 2021. https://www.emav.be/position-papers

FAO (Food and Agriculture Organisation of the United Nations). 2018. Fishery and Aquaculture Statistics. Global production by production source 1950-2028 (FishstatJ). In: FAO Fisheries and Aquaculture Department [online]]. Rome. Updated 2018. www.fao.org/fishery/statistics/software/fishstatj/en

FAO (Food and Agriculture Organisation of the United Nations). 2022. The State of World Fisheries and Aquaculture 2022. Towards Blue Transformation. Rome, FAO.

https://doi.org/10.4060/cc0461en

FEAP (Federation of European Aquaculture Producers). (2021) European aquaculture production report 2014-2020. https://feap.info/wp-content/uploads/2022/03/production-report-v1.1.pdf

Feng, Y., Shi, C., Ouyang, P., Huang, X., Chen, D., Wang, Q., ... & Geng, Y. (2022). The national surveillance study of grass carp reovirus in China reveals the spatial-temporal characteristics and potential risks. Aquaculture, 547, 737449.

Grein, K., Jungbäck, C., and Kubiak, V. (2022) Autogenous vaccines: Quality of production and movement in a common market. Biologicals. 2022 ISSN 1045-1056. https://doi.org/10.1016/j.biologicals.2022.01.003.

Henriksson PJG, Rico A, Troell M, et al. (2018) Unpacking factors influencing antimicrobial use in global aquaculture and their implication for management: a review from a systems perspective. Sustain Sci.13(4):1105-1120.

Jungbluth, S., Depraetere, H., Slezak, M., Christensen, D., Stockhofe, N., & Beloeil, L. (2022). A gaps-and-needs analysis of vaccine R&D in Europe: Recommendations to improve the research infrastructure. Biologicals, 76, 15-23.

Love DC., Fry JP., Cabello F., Good CM., Lunestad BT. 2020. Veterinary drug use in United States net pen Salmon aquaculture: Implications for drug use policy. Aquaculture, 518: 734820. https://doi.org/10.1016/j.aquaculture.2019.734820

Luu QH, Nguyen TBT, Nguyen TLA, Do TTT, Dao THT, Padungtod P. Antibiotics use in fish and shrimp farms in Vietnam. Aquaculture Reports. 2021;20: 100711

Saléry M. 2017. Autogenous vaccines in Europe - national approaches to authorisation. Regulatory rapporteur, Topra, 2017, 14 (6), pp.27-30. ⟨anses-01570260⟩

Palić, D. and Scarfe, A.D. (2018). Biosecurity in Aquaculture: Practical Veterinary Approaches for Aquatic Animal Disease Prevention, Control and Potential Eradication. Chapter 19 pp 497-520 in Biosecurity in Animal Production and Veterinary Medicine (First Edition), Dewolf, J. and F. Van Immersel (eds). Published February 2018 by ACCO Uitgeverij, Leuven, Belgium. ISBN: 9789463443784.

Pridgeon, J.W. and Klesius, P.H. (2012) Major bacterial diseases in aquaculture and their vaccine development. CABI Reviews, CABI International. doi: 10.1079/PAVSNNR20127048.

EU. 2021. Regulation (EU) 2016/429 of the European parliament and of the council of 9 March 2016 on transmissible animal diseases and amending and repealing certain acts in the area of animal health (‘Animal Health Law’). Official Journal of the European Union L 84/1. Consolidated text Document 02016R0429-20210421 (2021): Regulation (EU) 2016/429 of the European Parliament and of the Council of 9 March 2016 on transmissible animal diseases and amending and repealing certain acts in the area of animal health (Animal Health Law).

EU. 2022. Regulation (EU) 2019/6 of the European parliament and of the council of 11 December 2018 on veterinary medicinal products and repealing Directive 2001/82/EC. Official Journal of the European Union L 4/43. Consolidated text Document 02019R0006-20220128 (2022): Consolidated text: Regulation (EU) 2019/6 of the European Parliament and of the Council of 11 December 2018 on veterinary medicinal products and repealing Directive 2001/82/EC (Text with EEA relevance)

Scarfe, A.D. and Palić, D. (2020). Chapter 3 - Aquaculture biosecurity: Practical approach to prevent, control, and eradicate diseases. Editor(s): Kibenge, FSB, Powell, MD. Aquaculture Health Management, Academic Press, 2020. Pages 75-116, https://doi.org/10.1016/B978-0-12-813359-0.00003-8.

Scarfe, A.D. and Palić, D. (eds) (2017). Aquaculture Biosecurity Manual and Workbook. IABVC Aquatic Veterinary Biosecurity Workshop, Cape Town, South Africa, July 01-02, 2017.

Smith P. Antimicrobial resistance in aquaculture. Rev Sci Tech off Int Epizoot. 2008;27(1):243-264.].

Sommerset I, Krossoy B, Biering E, Frost P. Vaccines for fish in aquaculture. Expert Review Vaccines. 2005;4(1):89-101

NVI (The Norwegian Veterinary Institute). (2016). Use of Antibiotics in Norwegian Aquaculture. Report on behalf of Norwegian Seafood Council Published by

The Norwegian Veterinary Institute Pb 750 Sentrum, 0106 Ös.

Thiang EL, Lee CW, Takada H, et al. Antibiotic residues from aquaculture farms and their ecological risks in Southeast Asia: a case study from Malaysia. Ecosyst Health Sust. 2021;7(1):1926337

Thwaite R, Li A, Kawasaki M, Lin C, Stephens F, Cherrie B, Knuckey R, Landos M, and Barnes AC. 2022. Longitudinal field survey during deployment of an emergency autogenous vaccine against Betanodavirus in farmed giant grouper (Epinephelus lanceolatus): Multiple factors contribute to outbreaks and survival. Aquaculture, 548, Part 1, 2022, 737599, ISSN 0044-8486, https://doi.org/10.1016/j.aquaculture.2021.737599.

WOAH (World Organisation for Animal Health). 2021. Aquatic Animal Health Code and Manual, 06.09.2021. WOAH, Paris.

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